Fludrocortisone induced abdominal aortic pathology locates in the suprarenal aorta, the same location for AngII-induced AAAs [5,6,9] mice with endothelial nitric oxide synthase [20], mice administered deoxycorticosterone acetate and high salt, and mice administered aldosterone and high salt [21]. This evidence concerns the gene NOS3 and achalasia-alacrima syndrome.