APOE and thoracic aortic aneurysm: AngII-induced abdominal aortic aneurysms (AAA) are augmented under hypercholesterolemic conditions such as LDLR deficiency or apolipoprotein E (ApoE) deficiency, whereas AngII-induced thoracic aortic aneurysms (TAA) are not associated with hypercholesterolemia [12,13].