Taken together, these results suggest that the new infection biomarker SCD14-ST, in addition to new generation inflammatory biomarkers, such as SuPAR, sRAGE, and the cytokines IL-6 and IL-10, can be a useful prognostic tool associated with canonical inflammatory parameters, such as CRP, to predict the SARS-CoV-2 outcome in ICU patients. This evidence concerns the gene IL6 and infection.