PRF1 and neoplasm: Apart from the typical MV markers, the natural-killer-derived MVs (NKMVs) carry surface molecules and internal loads (e.g., perforin, granzymes, granulysin, CD40L, and miRNAs associated with anti-tumor activity) that can effectively support defective immunological activities, similar to those of the parent cells in vitro and in vivo, through crosstalk with both immune and infected/tumor cells [63,64].