Thus, here we have evaluated the effect of PARP1 inhibition in peripheral blood cells (PBMCs) obtained from healthy human volunteers following exposure of the cells to bacteria, bacterial pro-inflammatory components, or oxidative stress and assessed the effect of the PARP inhibitor on cell functions related to host response to infection: phagocytosis, ROS and NO generation, microbicidal activity, and cytokine production. Here, PARP1 is linked to infection.