Several other reports have demonstrated miRNA playing a biological role in pancreatic cancer pathways, such as those targeting TXNIP-Mediated HIF1α [39], E2F5 [40], TGF-β2/TGF-βRIII [41], HIF1α [42], and PTEN [43]. The gene discussed is E2F5; the disease is familial pancreatic carcinoma.