TPT1 and familial pancreatic carcinoma: It has been shown that miR-216b-5p expression is significantly decreased in pancreatic cancer tissues and cell lines, and its overexpression was positively correlated with pancreatic cancer cell proliferation, induced cell cycle arrest and cell apoptosis in vitro and inhibited tumorigenesis in vivo, acting as a potential tumor suppressor by regulating TPT1 [37].