ACTA2 and hemangioma: Previous published data, combined with ACTA2 upregulation in involuting hemangioma, suggest that hemangioma pericytes play an important role in hemangioma involution via at least two possible mechanisms: (1) increased number and contractility of hemangioma-derived pericytes influencing capillary maturation and perfusion, and (2) the ability of hemangioma pericytes to transdifferentiate into myofibroblasts favoring HEMA.