CD8A and neoplasm: If the immune system fails to completely eradicate the tumor and restore homeostasis, evolution of the cancer cells though stochastic events and the process of natural selection leads to clones that evade anti-tumor immune responses, usually through a combination of processes that make them “invisible” to anti-tumor effector cells (e.g., CD8+ cytotoxic T lymphocytes (CTLs), NK cells, etc.)[71].