Knockdown of Rab27a in orthotopically implanted KPC cancer cells (shRab27a-KPC) altered the liver microenvironment by decreasing MDSC frequencies, including CD11b+Ly6C+Ly6G+ granulocytic cells, CD11b+Ly6C+Ly6G− monocytic cells and CD11b+Ly6C−Ly6G− macrophages compared to the liver microenvironment in mice inoculated with control KPC cells (scr-KPC) [21]. The gene discussed is ITGAM; the disease is cancer.