Additionally, BC patients, unselected for family history of cancer (i.e., unknown cancer risk), admitted to a cancer reference hospital (Erasto Gaertner Hospital, Group 3) were tested for TP53 p.R337H and XAF1 p.E134* to obtain the genotype and allele frequencies of theses mutations in BC in Paraná state. The gene discussed is XAF1; the disease is cancer.