In xenograft mouse experiments that observe the effects of YAP and LATS2 O-GlcNAcylation on tumor growth, tumors from grafts expressing an O-GlcNAcylation-deficient YAP (S109A or T241A) or LATS2 (T436A) mutant are significantly smaller than those from grafts expressing wild-type YAP or LATS2 [9,10,12]. This evidence concerns the gene LATS2 and neoplasm.