In a recent study, MDA-MB-231 breast tumor cells and lymphatic–tropic derived cells secreted VEGF-C to prime LEC remodeling and subsequent chemokine/CXCR2 interaction to drive MDSC recruitment in a breast cancer orthotopic murine model [24], thus highlighting the importance of incorporating all of these cell types in our model. This evidence concerns the gene VEGFC and breast carcinoma.