The first consistent report on the activity of the Notch pathway in CLL [6] revealed that expression of NOTCH1, NOTCH2 and their ligands Jagged 1/2 was common and at odds with normal B lymphocytes, possibly due to deregulated protein turnover rather than differences in gene transcription and/or mRNA stability. The gene discussed is NOTCH1; the disease is B-cell chronic lymphocytic leukemia.