Using ChIP-seq experiments, they confirmed not only the capacity of NOTCH1 to induce MYC transcription, but the usage by NOTCH1 of the same B-cell specific 5′ enhancers previously described in lymphoma; interestingly, copy-number analyses suggested that this enhancer region is recurrently affected by focal duplications, mutually exclusive with NOTCH1 mutations. This evidence concerns the gene NOTCH1 and lymphoma.