In comparison with previously reported cancer-associated hypoxia-related signatures (Buffa [34], Winter [35], Eustace [36] and Ragnum [37]), only 6% of the genes in the HIF-PPGL profile were also in any of those signatures (Figure 1B, Supplementary Table S4) and these were mostly involved in glycolysis and HIF1α pathway, indicating that genetically determined pseudohypoxia and cancer-associated genuine hypoxia have different features. This evidence concerns the gene HIF1A and cancer.