NR2F1-high primary breast cancer amplified multiple pathways related to metastasis: Epithelial Mesenchymal Transition (EMT), angiogenesis, as well as enhanced cancer stem cell-related pathways, including KRAS signaling, Notch signaling, Hedgehog signaling, and Wnt/β-catenin signaling (Figure 1D). The gene discussed is KRAS; the disease is cancer.