In gastric cancer cachexia, Terawaki K et al. observed that LIF expression was up-regulated, with the elevated expression of orexigenic neuropeptides including neuropeptide Y (NPY), agouti-related protein (AgRP), orexin (ORX), and melanin-concentrating hormone (MCH), and the inhibited expression of anorexigenic neuropeptides, including POMC, amphetamine-regulated transcript (CART), and corticotropin-releasing hormone (CRH) in the hypothalamus [39]. Here, LIF is linked to gastric cancer.