ANGPT2 and neoplasm: Significant upregulation of tissue and blood ANG2 levels has been reported in many types of cancer, including melanoma, glioblastoma, breast cancer, renal cell carcinoma, colorectal cancer, and GC [14,17,59,60], but the transference of ANG2 via tumor EVs into the microenvironment has only been reported in hepatocellular carcinoma (HCC).