MMP13 and neoplasm: As for the ratio between pro- and antiangiogenic properties of tumor-derived EVs, a recent study demonstrated that exosomes from nasopharyngeal carcinoma cells contain high levels of proangiogenic proteins including CD44 isoform 5, ICAM-1, and MMP13, in contrast to low levels of the antiangiogenic protein, thrombospondin-1 [56].