Based on an unsupervised hierarchy, the patients were divided into four main groups; the basal-like/triple-negative group was the most prominent (11% of all cases), the luminal A cancers containing the Her2- and ER+/PR+ tumors was the largest group (57%), and the group of luminal B (32%) was more heterogeneous and contained the Her2+/ER− patients as well. This evidence concerns the gene ESR1 and cancer.