NPC1L1 and cancer: As well, DTP cells are sensitive to the unusual cytoplasmic vacuolization process of methuosis (or excessive macropinocytosis) and disequilibrating Niemann–Pick C1-like 1 (NPC1L1)-mediated redox control by promoting the permeation of anti-cancer agents and inciting catastrophic and expeditious fluid uptake [192,196,197,198,207,208].