In general, RRM2 was positively related to TMB in 16 types of cancers: ACC, BLCA, BRCA, COAD, CHOL, KICH, KIRC, LGG, LUAD, LUSC, PAAD, PRAD, SARC, SKCM, STAD and UCEC (p < 0.05, Figure 8B). The gene discussed is RRM2; the disease is cancer.