RRM2 and cancer: Consistently, overexpression of RRM2 was discovered in 28 cancers via GTEx-TCGA: ACC, BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LAML, LIHC, LGG, LUAD, LUSC, OV, PAAD, PCPG, PRAD, READ, SKCM, STAD, TGCT, THYM, THCA, UCS and UCEC (Figure 1B).