RRM2 and cancer: RRM2 high expression was linked to a dismal OS in several cancers from GEO (Figure 4J), including BRCA (HR = 2.41, p < 0.001), GBM (HR = 1.94, p < 0.001), LUAD (HR = 1.97, p < 0.001), LUSC (HR = 1.54, p = 0.047), PRAD (HR = 1.34, p < 0.001) and SKCM (HR = 3.46, p = 0.002).