Lee et al. analysed hypermutated MSS CRC with BRCA1/2 somatic truncations using all stages of CRC from TCGA PanCancer study as a discovery set (n = 21) and the metastatic CRC subset of MSK-IMPACT (Memorial Sloan Kettering Cancer Center [MSKCC]) as a validation cohort (n = 41). This evidence concerns the gene BRCA1 and colorectal carcinoma.