In addition, a series of studies have proved that Ganoderma lucidum spore polysaccharide (GLSP) [337], CMPB90-1 [338], natural M1 exosomes [339], conditional deletion of the microRNA (miRNA)-processing enzyme DICER [334] and TLR 7/8 agonist [57] can specifically eliminate M2-like phenotype or reset TAM from M2-like phenotype to M1-like phenotype to inhibit tumor development and reverse tumor treatment resistance. This evidence concerns the gene DICER1 and neoplasm.