Transcriptional analysis in drug-resistant CRC cell lines showed that enhanced FGFR4 activity confers chemotherapeutic resistance, and FGFR4 silencing downregulation of anti-apoptotic proteins c-FLIP and Bcl-2 and decreasing STAT3 activity reverse the sensitivity of CRC to chemotherapy [50]. Here, STAT3 is linked to colorectal carcinoma.