NOX4 and colorectal carcinoma: NOX4 expression is closely related to CAF accumulation in myofibroblasts in patients with CRC, which may be attributed to the fact that NOX4 regulates the transdifferentiation from fibroblasts to myofibroblasts through the delayed period of intracellular ROS production, and the inhibition of NOX4 can effectively reduce the accumulation of CAF [53].