CAF-expressing Snail participates in CRC resistance to 5-FU/paclitaxel chemotherapy by secreting CCL1 to activate TGF-β and NF-κB signaling pathways, and inhibition of TGF-β and/or NF-κB signaling pathway can reverse CCL1-mediated multi-drug resistance [297]. This evidence concerns the gene NFKB1 and colorectal carcinoma.