Current studies have shown that activation of the Wnt/β-catenin signaling pathway can mediate CRC resistance to chemotherapy through several pathways, such as upregulation of MDR1, inhibition of apoptosis, maintenance of stem cell dryness, regulation of epithelial-mesenchymal transformation (EMT) and regulation of tumor microenvironment [191]. Here, ABCB1 is linked to colorectal carcinoma.