CDH1 and neoplasm: Additionally, pseudo-hemorrhage was observed with characteristics demonstrating how abundant vessel endothelial cells were divorced from vessel dilation to create blood-filled caverns with no endothelial cell boundary in insulinoma, and it was encircled by tumor cells with increased E-cadherin and β-catenin expression [97], implying that it was connected to the epithelial–mesenchymal transition process of tumor cells.