WWTR1 and pancreatic neuroendocrine tumor: Multiple omics methods are used to reveal and analyze pancreatic NET specimens, with four subgroups having been identified: proliferation, PDX1-high, alpha cell-like, and stromal/mesenchymal subsets, and the stromal/mesenchymal subsets are rich in stromal and immune cells and are related to the molecular characterization of YAP1/WWTR1 (TAZ) activation, suggesting the role of the Hippo signaling pathways in this process [132].