PDCD1LG2 and pancreatic neuroendocrine tumor: In pancreatic NETs, immunosuppressive genes, including PD-L1, PD-L2, C10orf54, lymphocyte-activation gene 3, and indoleamine 2,3-dioxygenase 1, are rich in metastasis-like primary-1 subtype classification (accounting for 26–31% of patients) for T cell and M1 macrophage modulation [79].