Genome-wide sequencing revealed a recurrent somatic mutation G17V in the small GTPase ras homology family member A (RHOA) in 50 to 70% of AITL cases [23], together with genetic alterations in the epigenetic modifier genes, principally tet methylcytosine dioxygenase 2 (TET2) and, more rarely, DNA methyltransferase 3 alpha (DNMT3A) or isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2), and signaling factors (e.g., FYN and CD28) [24,25,26]. This evidence concerns the gene DNMT3A and angioimmunoblastic T-cell lymphoma.