Protein levels of beclin-1 and LC3B were significantly greater in the gastrocnemius and diaphragm (p = 0.08, beclin-1) of cancer cachexia mice than in the non-cachectic controls, and treatment with rucaparib significantly reduced those levels in the cachectic animals (Figure 8A,D–G, respectively). Here, BECN1 is linked to Cachexia.