WNT5A and Familial prostate cancer: In addition, several members of the WNT family were found to be differentially expressed in osteotropic prostate cancer cell lines (such as PC-3) compared to non-osteotropic ones (such as LNCaP and DU-145) [184], and knockdown of some of these members (e.g., WNT5A and FZD) decreases prostate cancer cell invasion [185].