IL1A and cancer: In the TME, IL-1α secreted from OSCC cells is not only able to promote the proliferation of CAFs but can also upregulate the secretion of cytokines, including the C-C motif ligand (CCL) 7, the C-X-C motif ligand (CXCL) 1, and IL-8, that promote cancer progression in human OSCC patients [30].