The results of the study showed that dysregulation from baseline measurements of four previously identified protein markers (CA125, phosphatidylcholine-sterol acyltransferase (LCAT), vitamin K-dependent protein Z (PROZ), and CRP [119]), could be used to identify women that subsequently develop ovarian cancer, with an AUC of 0.848 for OC samples that were 1–2 years prior to time of diagnosis [120]. This evidence concerns the gene MUC16 and ovarian cancer.