MDS/AML-associated cytogenetic alterations were detected in CD34+ cells exposed to the recombinant proteins such as tetraploidies, loss/gain of chromosomes such as −5, +8, +11, −17, +19, +21, chromatid breaks such as chtb(7q) and chtb(5q), chromosome breaks such as chsb(5q) and one translocation t(5;18). The gene discussed is CD34; the disease is myelodysplastic syndrome.