IRE resulted in longer survival and more proliferating CD8+ T cells in the tumor and spleen. Both memory and effector CD8+ T cells were increased in the tumor and the tumor-draining lymph node regions. The viable region showed increased microvessel density and softening of the extracellular matrix.Mice that were re-challenged with pancreatic cancer cells after IRE rejected the tumor challenge. Here, CD8A is linked to neoplasm.