CD8A and neoplasm: Five key events have been linked to effective priming of the T cells: (I) release of tumor-associated antigens (TAAs), (II) release of damage-associated molecular patterns (DAMPs), (III) uptake and processing of TAAs by antigen-presenting cells (APCs), (IV) antigen presentation by APCs to naïve T cells, and finally (V) activation and proliferation of cancer-specific CD8+ T cells [7,8].