PIK3CA and inflammatory breast carcinoma: In a pooled analysis of next-generation sequencing data from 101 IBC and 2351 non-IBC tumors, Bertucci et al. demonstrated that the Notch and DNA repair pathways were more frequently targeted by genomic alterations in IBC than in non-IBC, whereas PIK3CA was the only gene that was more frequently altered in non-IBC (39.2% vs. 20.8% in IBC) [51].