In fact, Hu et al. reported a false-positive plasma genotyping due to clonal hematopoiesis where most JAK2 mutations, some TP53 mutations, and rare KRAS mutations detected in cfDNA were derived from clonal hematopoiesis instead of the tumor as mutations detected in plasma, particularly in genes mutated in clonal hematopoiesis, which might not represent the true tumor genotype, the study concluded [31]. This evidence concerns the gene TP53 and neoplasm.