A summarization about the curcumin potential against luminal A-derived breast cancer stem cells includes (i) the decrease in self-renewal/stemness marker(s) expression, (ii) the possessed radio-sensitization and chemo-sensitization potential, (iii) targets AMPK, STAT3, and NF-ĸB signaling pathways and hypoxia-related markers, (iv) decreases the expression of multi-drug resistance transporters (ABCG2), and (v) the possessed synergetic anti-breast cancer stem cell potential. This evidence concerns the gene STAT3 and breast cancer.