The published literature thus far suggests the effect of genistein against luminal A-derived BCSCs through the (i) downregulation of the Hedgehog and PI3K/Akt pathway, (ii) suppression of the oncogenic transcription factors and (iii) inhibition of the mammosphere formation in ER− breast cancer cells in a paracrine manner. The gene discussed is AKT1; the disease is breast carcinoma.