However, on the other hand, expression of CAV1 in cancer cells lacking E-cadherin, which is lost in cancer development during the epithelial to mesenchymal transition [43,44], enhances the metastatic potential by a pathway involving CAV1 phosphorylation on Y14 and activation of the Rab5-Rac1 signaling axis [38,41]. This evidence concerns the gene RAC1 and cancer.