Notably, pSTAT1 or pSTAT6 inhibitors could remarkably suppress the LC3-II expression and reduced the ratio of LC3-II/LC3-I (Figure 5E–H), implying that IFI35-mediated autophagy was inhibited by the inhibitor in IFI35-deleted renal cancer cells. The gene discussed is IFI35; the disease is renal carcinoma.