Taken together, the genomic data from the two TCGA colorectal cancer cohorts suggest that MCC is silenced by CpG island hypermethylation in CIMP-H colon cancers, while low MCC expression is associated with other factors in non-CIMP cancers, such as shore/shelf hypomethylation and gene deletions. This evidence concerns the gene MCC and malignant colon neoplasm.