CPX-351 seems to exhibit potent and direct ex vivo cytotoxicity against AML blasts harboring the FL3-ITD mutation [54], while other genomic predictors of response to CPX-351 have been described such as ASXL1 and RUNX1 mutations, which were not associated with a lower ORR [37]. This evidence concerns the gene ASXL1 and acute myeloid leukemia.