The mechanisms by which JMJD2D promotes the pathogenesis of CRC and HCC have been preliminarily clarified, while the facilitator role of JMJD2D in other malignancies has also been reported, including gastrointestinal stromal tumor (GIST), acute myeloid leukemia (AML), renal cell carcinoma (RCC), and esophageal squamous cell carcinoma (ESCC) [105,106,107,108]. The gene discussed is KDM4D; the disease is renal cell carcinoma.