JMJD2D is highly expressed in tumor tissues of CRC patients; knockdown or knockout of JMJD2D in CRC cells can suppress their proliferation in vitro and inhibit the growth of xenograft tumors and the metastasis to lung or liver in vivo; similarly, the formation of AOM/DSS-induced CRC is also attenuated in JMJD2D−/− mice [35]. The gene discussed is KDM4D; the disease is infectious otitis media.