Knockout of JMJD2D in mouse CRC cells inhibits CRC growth in both normal immune C57BL/6 mice and immunocompromised nude mice [67]; however, the proportion of tumor reduction in normal immune C57BL/6 mice is higher than that in immunocompromised nude mice, most likely due to the increased contribution of tumor-infiltrating CD8+ T cells [67]. This evidence concerns the gene CD8A and neoplasm.