ARNT and gastrointestinal stromal tumor: Hu and colleagues reported that JMJD2D promotes the progression of GIST by activating HIF1β/VEGFA signaling [105]; although they demonstrated that JMJD2D promotes the transcription of HIF1β by binding to its promoter to demethylate H3K9me3 and H3K36me3, the role of H3K36me3 remains to be determined as H3K36me2/3 is generally associated with active transcription.