In addition, the expression of the histological markers DAXX (p = 0.004), ATRX (p = 0.004), SSTR2A (p < 0.001), p53 (p < 0.001), and CgA (p = 0.020) that are used to distinguish between NET G3 and NEC in GEP-NEN also differed significantly among G3 tumors with high and low EZH2 expression (Figure 3H). The gene discussed is TP53; the disease is neuroendocrine carcinoma.