Among them, four APOBEC genes were considered to participate in biological functions for cancer, such as in the Cosmic database [17], the CancerMine database [18], and the TSGene database [19]; APOBEC3A was annotated as oncogenes, APOBEC3B was annotated as oncogenes and TSG (tumor suppressor gene), APOBEC3G was annotated as driver genes, and AICDA was annotated as oncogenes and driver genes. Here, APOBEC3B is linked to cancer.