CDH1 and cancer: In a tissue microarray study on 14,637 tumor samples from 112 different tumor types—including mesothelioma—the inversion of the E-cadherin expression pattern (downregulation of E-cadherin in cancers derived from E-cadherin positive tissues and upregulation of E-cadherin in cancers derived from E-cadherin negative tissues) was linked to aggressive histopathological tumor types and poor outcome [26].