The LPS treatment of NHDF did not change the relative CTSB mRNA expression compared to untreated NHDF, while the LPS treatment of PXE fibroblasts resulted in a slight 1.3 ± 0.2-fold increased expression level (p < 0.05) compared to untreated PXE fibroblasts. The gene discussed is CTSB; the disease is pseudoxanthoma elasticum (inherited or acquired).