The LPS treatment of NHDF resulted in a 505 ± 81-fold (p < 0.0001) increased IL1B mRNA expression compared to untreated controls, while PXE fibroblasts showed a 1932 ± 320-fold (p < 0.0001) increased IL1B expression level in comparison with untreated PXE cells. This evidence concerns the gene IL1B and Pseudoxanthoma elasticum.