In a different work by Watanabe et al., an engineered oncolytic adenovirus expressing tumor necrosis-alpha (TNFα) and interleukin-2 (IL2) (Ad5/3-E2F-D24-TNFa-IRES-IL2 or Ad-mTNFa-mIL2) was administered to humanized mice bearing pancreatic adenocarcinoma xenografts. Here, TNF is linked to pancreatic adenocarcinoma.