Moreover, the trafficking of NMDARs is impaired in HD through destabilization of the clathrin-mediated endocytotic complex that involves the NMDA receptors, huntingtin, and HIP1 [113], as well as diverse interactions of post-translationally modified mHtt with PSD95, leading to increased stability of NMDARs at extrasynaptic sites [136]. This evidence concerns the gene DLG4 and Huntington disease.