In HD, GADPH is sequestered into mHtt aggregates and HAP1 binds more tightly to mHtt, thereby reducing the interaction of HAP1/p150 glued with microtubules, likely accounting for the decreased transport of BDNF [2], while HIP1 is more weakly interacting with mHtt, which impair its function [262]. This evidence concerns the gene HAP1 and Huntington disease.