We found that Apoe-/- mice on certain genetic backgrounds such as C57BL/6 (B6), C3H/HeJ (C3H), and SWR/J develop significant hyperglycemia and T2D with fasting plasma glucose exceeding 250 mg/dL when fed a Western-type diet [27,28]. The gene discussed is APOE; the disease is type 2 diabetes mellitus.