LGALS3 and heart failure: In a study carried out in a group of 54 frail and 74 non-frail persons, the relationship between frailty and inflammation was evaluated, and it was observed that galectin-3 was increased in the frail group, for which the authors suggested that galectin-3 upregulation was associated with the development of heart failure and could interfere with mechanisms of premature senescence, accelerated aging and development of frailty [71].