Furthermore, on the one hand, it has been observed that high-dose radiotherapy has an immunosuppressive action by inducing an M2-like phenotype [105,106] and, on the other hand, SRT has a pro-immunogenic action with a decrease in CD8+ T-cell response and IFN production, allowing tumor overexpression of PD-L1 [5]. The gene discussed is CD8A; the disease is neoplasm.