For instance, TET3 is engaged by REST to regulate gene expression by hydroxymethylation; CPEB3 is a translational regulator; TNRC6B is a factor playing a role in miRNA- and siRNA-dependent post-transcriptional gene silencing; MYCN encodes the well-known proto-oncogene; FBXW7 is a tumor suppressor controlling proteasome-mediated degradation of oncoproteins and is mutated in tumors, including acute myeloid leukemia [38] and 25% of adult T-cell leukemia/lymphoma [39]; and FZD6 belongs to G-protein-coupling receptors playing a role in the non-canonical Wnt. Here, REST is linked to acute myeloid leukemia.