RUNX1 and acute myeloid leukemia: In particular, favorable prognostic factors include t(8;21)(q22;q22)/RUNX1-RUNX1T1, t(15;17)(q22;q21)/PML-RARA, NPM1-mutated AML, and CEBPA double mutation [6].AML with MLL translocations has variable outcomes, depending on the associated translocation and occurs more frequently in children compared to in adults [25].