MDM2 and acute myeloid leukemia: Currently, a phase I study (NCT03654716) is evaluating the efficacy of the dual MDM2/MDMX inhibitor, ALRN-6924, as a possible treatment for refractory solid tumor, brain tumor, lymphoma, or leukemia (in particular, r/r AML, ALL, mixed-lineage leukemia, biphenotypic leukemia, or other undifferentiated acute leukemia) in pediatric patients and young adults (aged from 1 to 21 years old).