FLT3 and acute myeloid leukemia: Quizartinib is a second-generation FLT3 inhibitor approved in Japan for the treatment of r/r FLT3-AML but has not been approved by other countries because of the lack of a significant benefit-to-risk ratio [108,109], although a recent clinical trial conducted in older patients unsuitable for intensive chemotherapy showed a median OS of 13.7 months in patients treated with quizartinib in combination with low-dose ARA C (LDAC) compared with 4.2 months in patients receiving LDAC alone, leading to a reconsideration of the role of quizartinib in FLT3-mutated AML [110].