This study revealed that fsCH enhanced the formation of trabecular bones and collagenous matrix in the metaphysis and diaphysis of OVX mice through reducing expression of the osteoclastic biomarkers of CAII, V-ATPase, and cathepsin K. Other investigations have shown that collagen hydrolysates have a beneficial effect on osteoarthritis and osteoporosis [31,32]. Here, CA2 is linked to osteoarthritis.