A selective inhibitor of fission, P110, has been shown to inhibit the interaction of fission proteins Fis1/Drp1, decreasing mitochondrial fission, and improving bioenergetics in models of ischemia, including primary cardiomyocytes, ex vivo heart models, and in vivo myocardial infarction [80]. The gene discussed is DNM1L; the disease is ischemia.