SMAD2 and gastric cancer: For example, bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) inhibited the TGF-β/EMT signaling pathway and suppressed the invasiveness of gastric tumors [77]; ASPP2 inhibited TGF-β1-induced EMT in GC cells by inhibiting in them the phosphorylation and nuclear accumulation of Smad2/3 [78]; and Ki26894, a TβR-I kinase inhibitor showed a decrease in invasiveness and EMT in GC [79].