Epithelial–mesenchymal transition (EMT) is a process in which a subset of tumor cells in the primary tumor switches off epithelial markers such as E-cadherin, and turns on mesenchymal markers such as S100 calcium-binding protein A4 (S100A4) [5] and vimentin, resulting in cell polarity loss, cytoskeletal reorganization, and the dissolution of adherens and tight junctions [6,7]. This evidence concerns the gene S100A4 and neoplasm.